Cysteine cathepsins (proteases)--on the main stage of cancer?
Cancer Cell
; 5(5): 409-10, 2004 May.
Article
en En
| MEDLINE
| ID: mdl-15144947
ABSTRACT
Cysteine cathepsins are involved in degradation of extracellular matrix, facilitating growth, invasion, and metastasis of tumor cells, in tumor angiogenesis, in apoptosis, and in events of inflammatory and immune responses. In this issue of Cancer Cell, demonstrate association of increased cathepsins activity with angiogenic vasculature and invasive fronts of carcinomas during tumorigenesis in transgenic mouse models using activity-based chemical probes and in vivo imaging. Moreover, this study shows that a broad-spectrum cysteine cathepsin inhibitor effectively blocks several stages of tumorigenesis in the RIP1-Tag2 transgenic mouse model, offering new therapeutic opportunities in cancer treatment.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Catepsinas
/
Neovascularización Patológica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Cell
Asunto de la revista:
NEOPLASIAS
Año:
2004
Tipo del documento:
Article
País de afiliación:
Eslovenia