Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.
FEMS Microbiol Lett
; 242(1): 101-8, 2005 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-15621426
ABSTRACT
Burkholderia pseudomallei, the etiological agent of melioidosis, is an animal pathogen capable of inducing a highly fatal septicemia. B. pseudomallei possesses three type III secretion system (TTSS) clusters, two of which (TTSS1 and TTSS2) are homologous to the TTSS of the plant pathogen Ralstonia solanacearum, and one (TTSS3) is homologous to the Salmonella SPI-1 mammalian pathogenicity island. We have demonstrated that TTSS3 is required for the full virulence of B. pseudomallei in a hamster model of infection. We have also examined the virulence of B. pseudomallei mutants deficient in several putative TTSS3 effector molecules, and found no significant attenuation of B. pseudomallei virulence in the hamster model.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Burkholderia pseudomallei
/
Melioidosis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
FEMS Microbiol Lett
Año:
2005
Tipo del documento:
Article