Chronic effects of social drinking in a card-sorting task: an event related potential study.
Clin Neurophysiol
; 116(2): 376-85, 2005 Feb.
Article
en En
| MEDLINE
| ID: mdl-15661115
ABSTRACT
OBJECTIVE:
The Wisconsin Card Sorting Task (WCST) is one of the most widely used neuropsychological tests of frontal lobe function, which is thought to be affected by regular alcohol use. The present study used a computer-adapted version of the WCST to assess the effects of chronic alcohol consumption on the brain.METHODS:
Participants (N=59) sorted cards according to an initially unknown sorting rule, which referred to shape, number, or color. The correctness of the chosen sorting rule was indicated by a feedback stimulus. This correct sorting rule had to be followed for a number of stimuli, and when it changed participants had to find out which rule had to be followed next. A distinction was made between early (correct sorting rule is unknown) and late trials (correct sorting rule is known and applied). To measure brain activity related during the task event related potentials (ERPs) were recorded to the target and feedback stimulus in light (N=14), moderate (N=16) and heavy (N=19) social drinkers and excessive alcohol users (N=10).RESULTS:
No differences in number of series completed or the reaction time in each trial, were found between the four groups. In contrast, a mid-frontal N1 component in reaction to the feedback stimuli did reveal differences between the four groups. In the light and moderate drinkers, on early feedback trials the N1 was larger relative to late feedback trials, but this effect was absent in the heavy social drinkers and excessive drinkers.CONCLUSIONS:
The reduced N1 effect with increasing alcohol intake could reflect abnormal allocation of attention or impaired conflict monitoring, possibly based on activity in the anterior cingulate cortex.SIGNIFICANCE:
Heavy social drinking and excessive drinking leads to changes in the mid-frontal N1 during feedback trials of the WCST.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conducta Social
/
Encéfalo
/
Consumo de Bebidas Alcohólicas
/
Potenciales Evocados
/
Procesos Mentales
/
Pruebas Neuropsicológicas
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Neurophysiol
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Países Bajos