Antibody neutralization of vascular endothelial growth factor (VEGF) fails to attenuate vascular permeability and brain edema in experimental pneumococcal meningitis.
J Neuroimmunol
; 160(1-2): 170-7, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15710470
ABSTRACT
To determine the contribution of vascular endothelial growth factor (VEGF) to cerebral edema formation in bacterial meningitis, we used a VEGF neutralizing antibody to block VEGF in rabbits, following induction of meningitis by intracisternal inoculation with 10(9) heat-killed pneumococci. At 8 h, cerebrospinal fluid (CSF) VEGF was significantly elevated in infected untreated animals, and correlated with CSF white blood cell (WBC) count (r=0.56, P=0.004), and brain water content (r=0.42, P=0.04). Blocking of VEGF did not attenuate brain edema, blood-brain barrier disruption, or CSF pleocytosis. The functional role of VEGF in the pathophysiology of BM remains elusive.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Edema Encefálico
/
Permeabilidad Capilar
/
Anticuerpos Bloqueadores
/
Factor A de Crecimiento Endotelial Vascular
/
Meningitis Neumocócica
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Neuroimmunol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Países Bajos