c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
Proc Natl Acad Sci U S A
; 102(20): 7286-91, 2005 May 17.
Article
en En
| MEDLINE
| ID: mdl-15857952
ABSTRACT
The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ploidias
/
Proteínas Proto-Oncogénicas c-myc
/
Hepatocitos
/
Proliferación Celular
/
Tamaño de la Célula
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2005
Tipo del documento:
Article
País de afiliación:
España