Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.
Eur J Med Chem
; 40(6): 597-606, 2005 Jun.
Article
en En
| MEDLINE
| ID: mdl-15922843
ABSTRACT
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pirimidinas
/
Inhibidores Enzimáticos
/
Inhibidores de Histona Desacetilasas
/
Ácidos Hidroxámicos
Límite:
Female
/
Humans
Idioma:
En
Revista:
Eur J Med Chem
Año:
2005
Tipo del documento:
Article
País de afiliación:
Francia