Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene.
Chem Biol Interact
; 153-154: 247-51, 2005 May 30.
Article
en En
| MEDLINE
| ID: mdl-15935822
ABSTRACT
Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Benceno
/
Biomarcadores
/
Exposición Profesional
/
Contaminantes Ocupacionales del Aire
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Chem Biol Interact
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos