Indole alkaloids and other constituents of Rauwolfia serpentina.
J Nat Prod
; 68(6): 848-52, 2005 Jun.
Article
en En
| MEDLINE
| ID: mdl-15974606
ABSTRACT
From the dried roots of Rauwolfia serpentina were isolated five new indole alkaloids, N(b)-methylajmaline (1), N(b)-methylisoajmaline (2), 3-hydroxysarpagine (3), yohimbinic acid (4), isorauhimbinic acid (5), a new iridoid glucoside, 7-epiloganin (6), and a new sucrose derivative, 6'-O-(3,4,5-trimethoxybenzoyl)glomeratose A (7), together with 20 known compounds. The structures of the new compounds were determined by spectroscopic and chemical means. The inhibitory activities of the selected alkaloids on topoisomerase I and II and their cytotoxicity against the human promyelocytic leukemia (HL-60) cell lines were assessed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Rauwolfia
/
Alcaloides Indólicos
/
Antineoplásicos Fitogénicos
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2005
Tipo del documento:
Article
País de afiliación:
Japón