GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases.
Nucleic Acids Res
; 33(Web Server issue): W758-61, 2005 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-15980578
ABSTRACT
The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker (http//www.cmbi.ru.nl/GeneSeeker/), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Programas Informáticos
/
Predisposición Genética a la Enfermedad
/
Bases de Datos Genéticas
/
Enfermedades Genéticas Congénitas
Límite:
Humans
Idioma:
En
Revista:
Nucleic Acids Res
Año:
2005
Tipo del documento:
Article
País de afiliación:
Países Bajos