Echocardiographic assessment of left ventricular morphology and function in patients with Emery-Dreifuss muscular dystrophy.
Int J Cardiol
; 102(2): 207-10, 2005 Jul 10.
Article
en En
| MEDLINE
| ID: mdl-15982486
ABSTRACT
BACKGROUND:
Emery-Dreifuss muscular dystrophy (EDMD) characterized by musculoskeletal abnormalities is often associated with atrioventricular conduction disturbances. Although some EDMD patients were reported to develop dilated cardiomyopathy, there are limited data on their left ventricular (LV) performance.METHODS:
Therefore, we echocardiographically assessed 27 men (23 cases aged 26.4+/-6.8 years with X-linked, and four cases aged 22.2+/-8.6 years with autosomal dominant (AD)) EDMD. Control group included 16 male healthy controls aged 24.8+/-6.0 (18-37) years.RESULTS:
Although LV end diastolic dimension was similar in EDMD and controls (4.9+/-0.6 and 4.99+/-1.1 cm, ns), dilated left ventricle was found in three X-linked EDMD subjects. LV ejection fraction was significantly reduced in EDMD (62.3+/-1% vs. 71.2+/-2%, p=0.01) and was below 50% in six (22.2%) X-linked EDMD patients. Doppler analysis disclosed prolonged isovolumetric relaxation time of the left ventricle in the studied group. This finding may indicate impaired LV relaxation.CONCLUSION:
A significant subgroup of X-linked EDMD patients shows pronounced abnormalities of left ventricular function. This warrants cardiologic follow up of EDMD patients.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cardiomiopatía Dilatada
/
Ecocardiografía Doppler
/
Función Ventricular Izquierda
/
Distrofia Muscular de Emery-Dreifuss
/
Ventrículos Cardíacos
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Int J Cardiol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Polonia