The histone chaperone SET/TAF-Ibeta interacts functionally with the CREB-binding protein.
Biochem Biophys Res Commun
; 335(2): 322-7, 2005 Sep 23.
Article
en En
| MEDLINE
| ID: mdl-16061203
ABSTRACT
The oncoprotein SET/TAF-Ibeta is a histone chaperone which is involved in cell-cycle control and chromatin remodeling. Confocal laser scanning microscopy reveals that SET is localized in distinct foci of variable size throughout the nucleoplasm of interphase cells. We report here that SET interacts directly with the acetyltransferase CREB-binding protein (CBP) and enhances the transactivation potential of the transcription coactivator. Our data suggest that the histone chaperone SET regulates the CBP-mediated transcription and may indicate a general principle by which transcriptional regulators cooperate with histone chaperones for gene activation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Proteínas Nucleares
/
Proteínas Cromosómicas no Histona
/
Histonas
/
Transactivadores
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2005
Tipo del documento:
Article
País de afiliación:
Grecia