The evidence for magnetic resonance imaging as an outcome measure in proof-of-concept rheumatoid arthritis studies.
J Rheumatol
; 32(12): 2465-9, 2005 Dec.
Article
en En
| MEDLINE
| ID: mdl-16331788
ABSTRACT
Magnetic resonance imaging (MRI) has now been used extensively in cross-sectional and observational studies as well as in controlled clinical trials to assess disease activity and joint damage in rheumatoid arthritis (RA). MRI measurements or scores for erosions, bone edema, and synovitis have been developed and validated by several groups. The OMERACT criteria require that outcome measures demonstrate adequate validity, discriminative power, and feasibility if they are to be useful in clinical trials. Specific performance targets for these criteria depend on the scientific, regulatory, logistical, and financial context of the study in question. We review the extent to which MRI assessments of joint erosion, bone edema, and synovitis fulfil these criteria, particularly as they relate to proof-of-concept RA clinical trials.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Imagen por Resonancia Magnética
/
Evaluación de Resultado en la Atención de Salud
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
J Rheumatol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido