Overgrowth caused by misexpression of a microRNA with dispensable wild-type function.
Dev Biol
; 291(2): 314-24, 2006 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-16443211
ABSTRACT
MicroRNAs (miRNAs) represent an abundant class of non-coding RNAs that negatively regulate gene expression, primarily at the post-transcriptional level. miRNA genes are frequently located in proximity to fragile chromosomal sites associated with cancers and amplification of a miRNA cluster has been correlated with the etiology of lymphomas and solid tumors. The oncogenic potential of a miRNA polycistron has recently been demonstrated in vivo. Here, we show that misexpression of the Drosophila miRNA mirvana/mir-278 in the developing eye causes massive overgrowth, in part due to inhibition of apoptosis. A single base substitution affecting the mature miRNA blocks the gain-of-function phenotype but is not associated with a detectable reduction-of-function phenotype when homozygous. This result demonstrates that misexpressed miRNAs may acquire novel functions that cause unscheduled proliferation in vivo and thus exemplifies the potential of miRNAs to promote tumor formation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
MicroARNs
/
Drosophila
/
Ojo
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Dev Biol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Suiza