The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor.
Bioorg Med Chem Lett
; 16(9): 2525-7, 2006 May 01.
Article
en En
| MEDLINE
| ID: mdl-16464581
ABSTRACT
Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved by the presence of one or two basic amine functional groups.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adenosina
/
Agonistas del Receptor de Adenosina A3
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos