[Chronic renal failure and growth hormone: effects on GH-IGF axis and leptin]. / Insuficiência renal crônica e hormônio de crescimento: efeitos no eixo GH-IGF e na leptina.
Arq Bras Endocrinol Metabol
; 49(6): 964-70, 2005 Dec.
Article
en Pt
| MEDLINE
| ID: mdl-16544021
ABSTRACT
AIM:
To analyze the changes in IGF-1, IGFBP-3, leptin and insulin after replacement doses of recombinant human growth hormone (rhGH) in short prepubertal children with chronic renal failure (CRF). PATIENTS ANDMETHODS:
Eleven children (3F8M), with mean age of 9.6 years, were treated with rhGH (0.23 mg/Kg weekly for 12 months). Serum leptin, insulin, glucose, IGF-1 and IGFBP-3 were measured before, 6 and 12 months after beginning rhGH treatment.RESULTS:
The serum levels of leptin, insulin and glucose did not vary during the treatment; normal leptin and glucose levels and high insulin were observed. There was a significant increment of IGF-1 and IGFBP-3 during the use of rhGH.CONCLUSIONS:
The replacement doses of rhGH during 12 months in a selected group of CRF children determined an increment in IGF-1 and IGFBP-3, associated to normal serum leptin and insulin resistance.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
/
Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina
/
Hormona de Crecimiento Humana
/
Terapia de Reemplazo de Hormonas
/
Leptina
/
Fallo Renal Crónico
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
Pt
Revista:
Arq Bras Endocrinol Metabol
Año:
2005
Tipo del documento:
Article