European guidelines for the management of chemotherapy-induced anaemia and health economic aspects of treatment.
Cancer Treat Rev
; 32 Suppl 2: S5-9, 2006.
Article
en En
| MEDLINE
| ID: mdl-16725267
ABSTRACT
Patients with cancer receiving myelosuppressive chemotherapy frequently develop anaemia; platinum-based chemotherapy, in particular, leads to reduced production of the bone marrow-stimulating hormone erythropoietin. The European Cancer Anaemia Survey showed that many patients do not receive erythropoiesis-stimulating agent (ESA) therapy and highlighted the need for clear guidelines for the diagnosis and treatment of anaemia in cancer patients. In response to a fast-moving therapeutic environment and guidelines produced in the USA, the European Organisation for Research and Treatment of Cancer established an independent task force to develop evidence-based guidelines for the use of ESAs in European anaemic cancer patients that were first published in 2004. The guidelines recommend that, in patients receiving chemotherapy/radiotherapy, ESA therapy should be initiated at haemoglobin levels of 9-11 g/dL based on the severity of symptoms (target haemoglobin concentration 12-13 g/dL) to improve quality of life and prevent the need for red blood cell transfusions. Treatment should be maintained as long as Hb levels remain <12-13 g/dL and patients continue to show symptomatic improvement, and should be discontinued, due to marginally elevated risks of thromboembolic events, when haemoglobin levels exceed 14 g/dL. Treatment of anaemia with ESAs is cost-effective and is associated with long-term gains in quality-adjusted life years.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Guías de Práctica Clínica como Asunto
/
Hematínicos
/
Anemia
/
Antineoplásicos
Tipo de estudio:
Guideline
/
Health_economic_evaluation
/
Qualitative_research
Límite:
Humans
País/Región como asunto:
America do norte
/
Europa
Idioma:
En
Revista:
Cancer Treat Rev
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia