Eosinophilic nasal polyps are a rich source of eotaxin, eotaxin-2 and eotaxin-3.
Rhinology
; 44(2): 145-50, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16792175
ABSTRACT
INTRODUCTION:
The CC-chemokine eotaxin plays a key role in the pathologic mechanism of tissue eosinophilia in nasal polyposis. In this study, we investigated a possible role of eotaxin-2 and eotaxin-3, the recently discovered members of the eotaxin family.METHODS:
Nasal polyps from 24 patients (non allergic/allergic/aspirin-intolerant patients) and turbinate tissue from 8 controls were investigated. Chemokine protein content (eotaxin, eotaxin-2, and -3) of tissue homogenates was measured by ELISA. Paraffin sections of samples were stained to determine the extent of eosinophilia.RESULTS:
Protein expression of eotaxin, eotaxin-2 and eotaxin-3 was significantly higher in nasal polyps than in controls. There was a direct correlation between the protein concentrations of all three eotaxins. Further, protein levels of all chemokines were significantly correlated to the amount of eosinophilia. In aspirin-sensitive polyps the number of eosinophils was significantly higher than in the other patient groups and they had significantly higher eotaxin, eotaxin-2, and -3 protein levels than non-allergic and significantly higher amounts of eotaxin-3 compared with allergic patients.CONCLUSIONS:
Our findings suggest, that all members of the eotaxin family are involved in the pathogenesis of nasal polyposis. The results are more likely indicative of a complex cooperation between all members of the eotaxin family than of a specific role in the development of eosinophilia and nasal polyposis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores Quimiotácticos Eosinófilos
/
Pólipos Nasales
/
Quimiocinas CC
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Eosinofilia
/
Eosinófilos
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Rhinology
Año:
2006
Tipo del documento:
Article
País de afiliación:
Alemania