Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.
Bioorg Med Chem
; 15(1): 142-59, 2007 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-17070062
ABSTRACT
A series of substituted glutaramides were synthesised using Candoxatrilat 1 as a lead and evaluated for potency against neutral endopeptidase (NEP) as a potential treatment for female sexual arousal disorder (FSAD). In this paper, we describe studies in which we were able to increase NEP activity substantially over the levels reported for previous compounds from this programme by appropriate substitution in both the P(1)(') and P(2)(') regions. Optimisation led to the 4-chlorophenpropylamide S-30 which was selected as a candidate for further study.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de Proteasas
/
Neprilisina
/
Disfunciones Sexuales Psicológicas
/
Ácidos Ciclohexanocarboxílicos
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Reino Unido