[Tissue array analysis of the aberrant expression of HLA class I molecules in human non small cell lung cancer].
Gan To Kagaku Ryoho
; 33(12): 1713-6, 2006 Nov.
Article
en Ja
| MEDLINE
| ID: mdl-17212084
ABSTRACT
A clinical significance of the aberrant expression of HLA class I molecules including HLA class I and HLA-G was analyzed using tissue array analysis. Our institute has established a two millimeter spot sized tissue array set of 105 clinical cases of resected human non small cell lung cancer tissues. A loss of HLA class I was observed in the 58.3% of cancer tissues. The aberrant expression of HLA G was also observed in the 55.2% of cancer tissues. Statistically significant correlations were observed among HLA class I expression and tumor size, nodal involvement and pathological stage. Survival analyses were shown that the HLA class I loss was correlated to a recurrence free survival time. The HLA-G expression did not correlate with any clinico-pathological parameters. A loss of HLA class I was probably involved due to a cancer progression in human non-small cell lung cancer through the mechanism of immune escape from the host immune system.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genes MHC Clase I
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Antígenos de Histocompatibilidad Clase I
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Carcinoma de Pulmón de Células no Pequeñas
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Análisis de Matrices Tisulares
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Antígenos HLA
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Neoplasias Pulmonares
Límite:
Aged
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Female
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Humans
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Male
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Año:
2006
Tipo del documento:
Article