Metzincins, including matrix metalloproteinases and meprin, in kidney transplantation.
Swiss Med Wkly
; 136(49-50): 789-94, 2006 Dec 23.
Article
en En
| MEDLINE
| ID: mdl-17299656
ABSTRACT
Chronic allograft nephropathy, including chronic rejection, remains one of the major causes of renal allograft failure. Amongst other mediators, metzincins, such as matrix metalloproteinases (MMP), direct extracellular matrix metabolism and cell proliferation. Thus, we hypothesized, that these proteolytic enzymes are differentially regulated in chronic renal transplant rejection in rats and in human renal allograft nephropathy. Our studies demonstrated on the experimental level and in humans an overall up-regulation of MMP, tissue inhibitors of metalloproteinases (TIMP) and related enzymes as a result of rejection processes. Thus, metzincins may represent novel markers and therapeutic targets with respect to renal allograft rejection.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
/
Inhibidor Tisular de Metaloproteinasa-2
/
Metaloproteinasas de la Matriz
/
Rechazo de Injerto
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Swiss Med Wkly
Asunto de la revista:
MEDICINA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Suiza