[Cytogenetic alterations in meningioma tumors and their impact on disease outcome]. / Alteraciones citogenéticas en meningiomas y su impacto en la evolución de la enfermedad.
Med Clin (Barc)
; 128(6): 226-32, 2007 Feb 17.
Article
en Es
| MEDLINE
| ID: mdl-17335728
ABSTRACT
In recent years important advances have been achieved in the understanding of the genetic abnormalities present in meningioma tumors and its association with the ontogeny and progression of these tumor. Accordingly, while the presence of monosomy 22/22q-, associated with mutation of the NF2, BAM22, RRP22, GAR22, MN1, SMARCB1, CLH22 and/or LARGE genes, is associated with neoplasic transformation, other alterations such us monosomy 14, del(1p), different chromosomal abnormalities localized at 9p, 10q and 17q and complex karyotypes are frequently related to tumor progression. From the clinical point of view, currently available information about the impact of the different cytogenetic abnormalities on disease behavior and patient outcome is still scanty; nevertheless, the presence of gains of chromosome 22 in the context of a hyperdiploid karyotype, as well as del(1p) and monosomy 14 have been associated with a statistically significantly shorter recurrence-free survival, this later abnormality showing an independent prognostic value.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Meníngeas
/
Meningioma
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Es
Revista:
Med Clin (Barc)
Año:
2007
Tipo del documento:
Article