Neuromotor outcome at 2 years of very preterm infants who were treated with high-frequency oscillatory ventilation or conventional ventilation for neonatal respiratory distress syndrome.
Pediatrics
; 119(4): e860-5, 2007 Apr.
Article
en En
| MEDLINE
| ID: mdl-17339385
ABSTRACT
OBJECTIVE:
In a previous multicenter, randomized trial, elective use of high-frequency oscillatory ventilation was compared with the use of conventional ventilation in the management of respiratory distress syndrome in preterm infants <30 weeks. No difference in terms of respiratory outcome was observed, but concerns were raised about an increased rate of severe intraventricular hemorrhage in the high-frequency ventilation group. To evaluate outcome, a follow-up study was conducted until a corrected age of 2 years. We report the results concerning neuromotor outcome.METHODS:
Outcome was able to be evaluated in 192 of the 212 infants who survived until discharge from the neonatal unit 97 of 105 infants of the high-frequency group and 95 of 104 infants of the conventional ventilation group.RESULTS:
In the infants reviewed, mean birth weight and gestational age were similar in the 2 ventilation groups. As in the overall study population, the following differences were observed between the high-frequency ventilation group and the conventional ventilation group lower 5-minute Apgar score, fewer surfactant instillations, and a higher incidence of severe intraventricular hemorrhage. At a corrected age of 2 years, 93 of the 97 infants of the high-frequency group and 79 of the 95 infants of the conventional ventilation group did not present any neuromotor disability, whereas 4 infants of the high-frequency group and 16 infants of the conventional ventilation group had cerebral palsy.CONCLUSIONS:
Contrary to our initial concern about the increased rate of severe intraventricular hemorrhage in the high-frequency ventilation group, these data suggest that early use of high-frequency ventilation, compared with conventional ventilation, may be associated with a better neuromotor outcome. Because of the small number of patients studied and the absence of any explanation for this finding, we can conclude only that high-frequency oscillatory ventilation is not associated with a poorer neuromotor outcome.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos Psicomotores
/
Síndrome de Dificultad Respiratoria del Recién Nacido
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Recien Nacido Prematuro
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Ventilación de Alta Frecuencia
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Ventilación con Presión Positiva Intermitente
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Recién Nacido de muy Bajo Peso
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Male
/
Newborn
Idioma:
En
Revista:
Pediatrics
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia