Chronic cocaine produces decreases in N/OFQ peptide levels in select rat brain regions.
J Mol Neurosci
; 31(2): 159-64, 2007.
Article
en En
| MEDLINE
| ID: mdl-17478889
ABSTRACT
The interaction of opioids and stimulants is well established; however, the mechanisms that underlie the role that opioid receptors play in psychostimulant action are not. Nociceptin/orphaninFQ (N/OFQ), the endogenous agonist at NOP receptors, attenuates the behavioral effects of cocaine. The effects of cocaine on N/OFQ were examined in rats using immunoautoradiographic and RIA techniques. Chronic administration of cocaine decreased N/OFQ in medial regions of the caudate putamen, the nucleus accumbens shell, and the substantia nigra. These studies show that N/OFQ levels are altered by treatment with cocaine. Furthermore, the changes in N/OFQ parallel those seen for kappa-opioid receptors, suggesting that the interactions between cocaine and these systems might be similar.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Putamen
/
Sustancia Negra
/
Núcleo Caudado
/
Cocaína
/
Péptidos Opioides
/
Estimulantes del Sistema Nervioso Central
/
Núcleo Accumbens
Límite:
Animals
Idioma:
En
Revista:
J Mol Neurosci
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEUROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia