X-chromosome inactivation in patients who have pigmented villonodular synovitis.
J Bone Joint Surg Am
; 73(10): 1532-6, 1991 Dec.
Article
en En
| MEDLINE
| ID: mdl-1748702
ABSTRACT
We performed a histological examination and DNA analysis on samples of tissue from a forty-seven-year-old woman who had a clinical diagnosis of pigmented villonodular synovitis. The histological examination confirmed the diagnosis. The evaluation of the samples of tissue with preferential X-chromosome inactivation analysis (a molecular biological method for the study of clonality in tumors) showed that the lesion was polyclonal in origin. We concluded, therefore, that pigmented villonodular synovitis is more likely to be a reactive process than a true neoplasm.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Membrana Sinovial
/
Sinovitis Pigmentada Vellonodular
/
Compensación de Dosificación (Genética)
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Bone Joint Surg Am
Año:
1991
Tipo del documento:
Article
País de afiliación:
Países Bajos