Determination of the cation-chelating potential of C-methylthiolated beta-lactams and their sulfones by electrospray ionization mass spectrometry.
Rapid Commun Mass Spectrom
; 21(13): 2051-8, 2007.
Article
en En
| MEDLINE
| ID: mdl-17534861
ABSTRACT
The chelation potential of highly lipophilic C-dimethylthiolated monocyclic beta-lactams was examined using electrospray ionization mass spectrometry (ESI-MS). The metal salts NaCl, KCl, CaCl2, ZnCl2, Cu(NO3)2, CdSO4, MnCl2, and Mg(NO3)2 were used for the analysis. The K+ adducts of the compounds studied were more responsive in ESI analysis, compared to their Na+ adducts, regardless of the oxidation state of the sulfur (in the methylthio or the sulfone groups) and the type of the group adjacent to the lactam carbonyl. Opening of the beta-lactam ring, leading to formation of a chargeable N-atom, had little to no effect on the K+ adduct formation. Interactions of the methylthio group with the divalent zinc ion were also observed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Espectrometría de Masas
/
Sulfonas
/
Espectrometría de Masa por Ionización de Electrospray
/
Beta-Lactamas
/
Metales
Idioma:
En
Revista:
Rapid Commun Mass Spectrom
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos