Interference of AlF4- with nucleotide and DNA binding of rat histone H1 in vitro. Implications for the pathogenesis of Alzheimer's disease.
Neurosci Lett
; 132(2): 171-4, 1991 Nov 11.
Article
en En
| MEDLINE
| ID: mdl-1784417
ABSTRACT
We demonstrate here that the H2PO4- analogue AlF4- binds to the nucleotide-binding site of rat liver histone H1 in vitro, and interferes with nucleotide recognition and H1 DNA binding. AlF4- may thus compromise the genetically determined pattern of protein synthesis through binding to H1, the general repressor. The present findings are of interest as a number of studies have implicated aluminium as a factor in the pathogenesis of Alzheimer's disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ADN
/
Histonas
/
Compuestos de Aluminio
/
Aluminio
/
Enfermedad de Alzheimer
/
Fluoruros
/
Flúor
/
Nucleótidos
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1991
Tipo del documento:
Article
País de afiliación:
Finlandia