Maintaining immunological tolerance with Foxp3.
Cell Res
; 17(11): 904-18, 2007 Nov.
Article
en En
| MEDLINE
| ID: mdl-17923863
ABSTRACT
Central tolerance in the thymus is the primary mechanism for deleting autoreactive T cells. Despite this, escape of self-reactive T lymphocytes into the periphery reveals the threat of autoimmunity. To compensate for its imperfection, the thymus also produces a naturally occurring subset of Foxp3+ CD4+ CD25+ regulatory T cells with suppressive function, capable of controlling autoreactive cells. Foxp3 (forkhead box P3), the lineage-specific marker for this subset of cells, is crucial to their thymic development and peripheral function, and yet the transcriptional program driven by Foxp3 was until now largely undefined. Emerging evidence has provided insight into its role from the ability of Foxp3 to cooperate with other transcription factors such as NFAT, to the genome-wide characterization of target genes directly bound and regulated by Foxp3. Here we discuss the discovery of naturally occurring regulatory T cells - their phenotype, development, maintenance, and function - largely as they are defined by the lineage-specific marker, Foxp3.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timo
/
Antígenos de Diferenciación
/
Regulación de la Expresión Génica
/
Factores de Transcripción Forkhead
/
Factores de Transcripción NFATC
/
Tolerancia Inmunológica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Res
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos