Synthesis of 2',5'-oligoadenylate analogs possessing a linker moiety in the place of the second adenosine and their ability to activate human RNase L.
Nucleic Acids Symp Ser (Oxf)
; (51): 449-50, 2007.
Article
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| MEDLINE
| ID: mdl-18029780
ABSTRACT
This paper describes the synthesis of 2',5'-oligoadenylate analogs possessing a linker moiety in the place of the second adenosine and their ability to activate human RNase L. Thus, 2-5A analogs (2a-c & 3a-c) possessing -O(CH(2)CH(2))nO- moieties (n = 1 approximately 3) or aromatic ring moieties were prepared. The EC(50) value of the 2-5A analog (2a) incorporating ethylene glycol showed 700 nM in RNase L activation activity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oligorribonucleótidos
/
Nucleótidos de Adenina
/
Endorribonucleasas
Límite:
Humans
Idioma:
En
Revista:
Nucleic Acids Symp Ser (Oxf)
Año:
2007
Tipo del documento:
Article
País de afiliación:
Japón