New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus.
Org Lett
; 10(2): 225-8, 2008 Jan 17.
Article
en En
| MEDLINE
| ID: mdl-18078344
ABSTRACT
Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D and 2D NMR spectra. Their absolute configurations were elucidated by the modified Mosher's method and chemical conversions. The new compounds showed cytotoxic activity against mouse lymphocytic leukemia cells (L1210).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Aspergillus
/
Macrólidos
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón