Increased vascular cell adhesion molecule-1 was associated with impaired endothelium-dependent relaxation of cerebral and carotid arteries in simulated microgravity rats.
J Physiol Sci
; 58(1): 67-73, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18221587
ABSTRACT
The aim of the present study was to investigate whether an expression of vascular cell adhesion molecule-1 (VCAM-1) was upregulated in 3-week simulated microgravity rat cerebral and carotid arteries and whether impaired endothelium-dependent relaxation was concomitant with VCAM-1 expression. Male Sprague-Dawley rats were randomly divided into control (CON) and hindlimb unweighting (HU) groups. After 3 weeks, the expression of the VCAM-1 protein and the vasodilatation of the basilar artery and common carotid artery were determined. Immunohistochemical results revealed positive staining of VCAM-1 on endothelial cells in these arteries from HU compared with CON rats. Western blot analysis confirmed an upregulated expression of VCAM-1 protein in these arteries from HU rats. Acetylcholine induced concentration-dependent vasodilatation in all artery rings, but with significantly smaller amplitude in the basilar artery (P < 0.01) and the common carotid artery (P < 0.05) from HU than those from CON rats. The data suggested that the expression of VCAM-1 protein was upregulated in cerebral and common carotid arteries of simulated microgravity rats, and the upregulation of VCAM-1 may contribute to impaired endothelium-dependent relaxation in simulated microgravity rat vasculature.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vasculitis
/
Vasodilatación
/
Arteria Basilar
/
Endotelio Vascular
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Arteria Carótida Común
/
Simulación de Ingravidez
/
Molécula 1 de Adhesión Celular Vascular
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Physiol Sci
Asunto de la revista:
FISIOLOGIA
/
TRAUMATOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
China