Lysinyl macrocyclic hexaoxazoles: synthesis and selective G-quadruplex stabilizing properties.
Bioorg Med Chem Lett
; 18(3): 913-7, 2008 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-18248989
ABSTRACT
Macrocyclic hexaoxazoles having one or two lysinyl side chains in which the terminal nitrogen is either a primary amine, N,N-dimethylamine, or an acetamide have been synthesized. Sodium ion has been found to be beneficial to the macrocyclization step by acting as a template around which the linear polyoxazole can organize. Each of the targeted compounds selectivity stabilizes G-quadruplex versus duplex DNA. Compounds with one valine and one lysine residue display the best combination of G-quadruplex stabilizing ability with no detectable stabilization of duplex DNA.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxazoles
/
ADN
/
Compuestos Macrocíclicos
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G-Cuádruplex
/
Lisina
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos