Middle cerebral artery occlusion in the rabbit using selective angiography: application for assessment of thrombolysis.
Stroke
; 39(5): 1613-5, 2008 May.
Article
en En
| MEDLINE
| ID: mdl-18340097
BACKGROUND AND PURPOSE: An animal model of selective middle cerebral artery (MCA) occlusion is needed for evaluation of intra-arterial (IA) delivery of thrombolytic agents. We describe a technique for MCA thrombo-occlusion in the rabbit with real-time angiographic documentation of occlusion and thrombolytic recanalization. METHODS: After femoral artery cutdown, a microcatheter was advanced from the internal carotid artery to the MCA. MCA occlusion was achieved by IA thrombin and reperfusion by IA plasmin. RESULTS: The terminal internal carotid artery was successfully catheterized in 12 of 13 animals. Stable (2-hour) MCA occlusion was induced and verified angiographically in all 12 animals; 2 animals also had distal internal carotid artery thrombus. Recanalization was achieved rapidly after IA plasmin in 3 of 3 animals. CONCLUSIONS: We describe a new animal model of selective MCA occlusion documented by real-time angiography and used to demonstrate recanalization with IA plasmin.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Angiografía Cerebral
/
Terapia Trombolítica
/
Infarto de la Arteria Cerebral Media
/
Embolia Intracraneal
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Stroke
Año:
2008
Tipo del documento:
Article