Family-based association of a low producing lymphotoxin-alpha allele with reduced Plasmodium falciparum parasitemia.
Microbes Infect
; 10(6): 673-9, 2008 May.
Article
en En
| MEDLINE
| ID: mdl-18457972
ABSTRACT
Tumor necrosis factor (TNF)-related genes are thought to play a role in human malaria. TNF polymorphisms have been associated with severe malaria, mild malaria, and parasitemia. Lymphotoxin-alpha gene (LTA) that belongs to the TNF family is one such candidate gene. Here we report the family-based association analysis of a cis-regulatory lymphotoxin-alpha polymorphism with parasitemia in two independent populations living in Burkina Faso. Analysis of 199 subjects (34 families) living in an urban endemic area revealed the association of the low producing LTA+80A allele with reduced parasitemia. Furthermore, there was evidence of significant LTA+80-by-age and LTA+80-by-gender interactions. In another set of 318 residents (55 families) in a rural endemic area, we found both the association of the low producing LTA+80A allele with reduced parasitemia and LTA+80-by-age and LTA+80-by-gender interactions. This study suggests that LTA+80 polymorphism influences parasitemia and acts in an age- and gender-dependent manner.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Polimorfismo Genético
/
Linfotoxina-alfa
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Factor de Necrosis Tumoral alfa
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Malaria Falciparum
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Parasitemia
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
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Adult
/
Animals
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Child
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Child, preschool
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Microbes Infect
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Francia