[Application of Lugol solution in the gastroesophageal reflux disease]. / Zastosowanie roztworu Lugola w chorobie refluksowej przelyku.

ABSTRACT

UNLABELLED Endoscopy examination followed by Lugol solution staining is used in the diagnostics of early squamous cell carcinoma of the esophagus. The aim of the study was to describe usage of this method for the assessment of effectiveness in the gastroesophageal reflux disease. The method uses reaction between glycogen, present in epithelium, and iodine in Lugol solution. The study was conducted in 98 patients. Endoscopic assessment was made before application of Lugol solution, subsequently the gastroesophageal borderline and staining of mucosa membrane after application of Lugol solution was assessed. Biopsies were taken from the stained and unstained areas. The performed study showed that sensitivity of the method is 84%, specificity 79% and effectiveness 85%. The ratio of stained and unstained areas is statistically typical p=0.045. CONCLUSIONS: Endoscopic examination followed by Lugol solution staining are sensitive diagnostic methods in the gastroesophageal reflux disease. It is a simple and quick method which should be widely applied.