Serum 25-hydroxyvitamin D status and cardiovascular outcomes in chronic peritoneal dialysis patients: a 3-y prospective cohort study.
Am J Clin Nutr
; 87(6): 1631-8, 2008 Jun.
Article
en En
| MEDLINE
| ID: mdl-18541550
ABSTRACT
BACKGROUND:
Patients with kidney disease are at high risk of developing 25-hydroxyvitamin D [25(OH)D] deficiency.OBJECTIVE:
We studied the association between serum 25(OH)D status and clinical outcomes of chronic peritoneal dialysis patients.DESIGN:
We measured serum 25(OH)D concentrations in 230 prevalent peritoneal dialysis patients and then followed these patients prospectively for 3 y or until death.RESULTS:
Serum 25(OH)D was deficient or insufficient (ie, <75 nmol/L) in 87% of the patients. Adjusting for clinical and demographic factors, every 1-unit increase in log-transformed serum 25(OH)D was associated with a 44% reduction in the hazard of fatal or nonfatal cardiovascular events (95% CI 0.35, 0.91; P = 0.018). However, the association was gradually lost when additional adjustment was made in a stepwise fashion for residual glomerular filtration rate (P = 0.078) and echocardiographic measures (P = 0.39). Kaplan-Meier estimates showed a significantly greater fatal or nonfatal cardiovascular event-free survival probability among patients with serum 25(OH)D > 45.7 nmol/L (median) than among patients with concentrationsCONCLUSIONS:
A lower serum 25(OH)D concentration was associated with an increased risk of cardiovascular events in chronic peritoneal dialysis patients. Furthermore, serum 25(OH)D status appeared to show a differential influence on the cardiovascular outcomes of peritoneal dialysis patients depending on the degree of left ventricular hypertrophy and systolic dysfunction.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Fenómenos Fisiológicos Cardiovasculares
/
Diálisis Peritoneal
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Clin Nutr
Año:
2008
Tipo del documento:
Article
País de afiliación:
Hong Kong