Subacute toxicity of polychlorinated naphthalenes and their effect on cytochrome P-450.
Ecotoxicol Environ Saf
; 72(2): 650-7, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-18722660
ABSTRACT
The aim of the study was to investigate the subacute toxicity of a polychlorinated naphthalene (PCN) mixture and its effect on cytochrome P-450 levels in rats. The animals were administered PCNs intragastrically in repeated daily doses of 1, 10, and 100 mg/kg. The animals were dissected after 7, 14, or 21 doses. Doses of 10 and 100 mg/kg induced a significant decrease in the body weight at all time points of the experiment compared with the control group. The exposure to PCNs increased both the level of total cytochrome P-450 and the activity of CYP 1A at the same time points. In the groups of rats given PCNs in doses of 10 and 100 mg/kg, an evident dose- and time-dependent increase in malondialdehyde (MDA) level was observed throughout the experiment. The correlation between the increased MDA and decreased glutathione (GSH) levels in the liver was also observed.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Peso Corporal
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Sistema Enzimático del Citocromo P-450
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Hidrocarburos Clorados
/
Hígado
/
Naftalenos
Límite:
Animals
Idioma:
En
Revista:
Ecotoxicol Environ Saf
Año:
2009
Tipo del documento:
Article
País de afiliación:
Polonia