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DNA methylation in development and human disease.
Gopalakrishnan, Suhasni; Van Emburgh, Beth O; Robertson, Keith D.
Afiliación
  • Gopalakrishnan S; Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL 32610, USA.
Mutat Res ; 647(1-2): 30-8, 2008 Dec 01.
Article en En | MEDLINE | ID: mdl-18778722
ABSTRACT
DNA methylation is a heritable and stable epigenetic mark associated with transcriptional repression. Changes in the patterns and levels of global and regional DNA methylation regulate development and contribute directly to disease states such as cancer. Recent findings provide intriguing insights into the epigenetic crosstalk between DNA methylation, histone modifications, and small interfering RNAs in the control of cell development and carcinogenesis. In this review, we summarize the recent studies in DNA methylation primarily focusing on the interplay between different epigenetic modifications and their potential role in gene silencing in development and disease. Although the molecular mechanisms involved in the epigenetic crosstalk are not fully understood, unraveling their precise regulation is important not only for understanding the underpinnings of cellular development and cancer, but also for the design of clinically relevant and efficient therapeutics using stem cells and anticancer drugs that target tumor initiating cells.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Metilación de ADN / Crecimiento y Desarrollo / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mutat Res Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Metilación de ADN / Crecimiento y Desarrollo / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mutat Res Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos