PDTC enables type I TRAIL signaling in type II follicular lymphoma cells.
Leuk Res
; 33(6): 829-36, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-18977530
ABSTRACT
Based on Bcl-X(L) overexpression studies we identified type I and type II follicular lymphoma cell lines in response to TRAIL. We demonstrate here that either amount of caspase-8 activation or Bid cleavage could not define the dependence on mitochondria. Furthermore, an inhibitor of NF-kappaB, PDTC, enabled TRAIL to activate type I apoptotic pathway in type II cells. However, an inhibitor of IKK did not switch apoptosis to type I pathway in type II cells, indicating that NF-kappaB might not be responsible for the switch.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tiocarbamatos
/
Prolina
/
Transducción de Señal
/
Linfoma Folicular
/
Ligando Inductor de Apoptosis Relacionado con TNF
/
Antineoplásicos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Leuk Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
Finlandia