Structures of beta-amino ester enolates: new strategies using the method of continuous variation.
J Am Chem Soc
; 130(51): 17334-41, 2008 Dec 24.
Article
en En
| MEDLINE
| ID: mdl-19090750
ABSTRACT
The solution structures of four enolates derived from beta-amino esters are investigated using (6)Li NMR spectroscopy in conjunction with the method of continuous variation (method of Job). Ensembles of homo- and heteroaggregated enolates are generated by mixing enantiomers of a single enolate (R/S mixtures), opposite antipodes of two different enolates (R/S' mixtures), and the same antipodes of two different enolates (R/R' mixtures). The numbers of observable aggregates and their dependence on the mole fraction of the two enolates confirm the hexamer assignments. Inherent symmetries observable in the (6)Li NMR spectra show the stereochemistry of chelation about the hexagonal drum.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Química Orgánica
/
Ésteres
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
J Am Chem Soc
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos