Synthesis of limonene beta-amino alcohol derivatives in support of new antileishmanial therapies.
Mem Inst Oswaldo Cruz
; 103(8): 773-7, 2008 Dec.
Article
en En
| MEDLINE
| ID: mdl-19148415
ABSTRACT
A series of seven limonene beta-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene beta-amino alcohol derivatives.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Terpenos
/
Leishmania braziliensis
/
Ciclohexenos
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Amino Alcoholes
/
Antiprotozoarios
Límite:
Animals
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Año:
2008
Tipo del documento:
Article
País de afiliación:
Brasil