Short synthesis of a novel class of salvinorin A analogs with hemiacetalic structure.
Tetrahedron Lett
; 49(6): 937-940, 2008 Feb 04.
Article
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| MEDLINE
| ID: mdl-19197341
ABSTRACT
Novel semisynthetic analogs of salvinorin A, a full agonist having extraordinary affinity as well as selectivity for the κ-opioid receptor (KOR), were obtained in good yields. The derivatives are remarkable for their unusual and unique hemiacetal structure in the salvinorin series of compounds. The formation of the hemiacetal occurs with epimerization at C-12, thus preserving the original configuration of salvinorin A. The dimethyl ester derivative of the hemiacetal was found to have an affinity for both KOR and MOR (µ-opioid receptor).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos