Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36.
Phytochemistry
; 70(3): 407-13, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-19230943
ABSTRACT
Isolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1-8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC(50) value of 5.30 microM.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ascomicetos
/
Depuradores de Radicales Libres
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Inhibidores de la Aromatasa
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Éteres
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Depsidos
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Lactonas
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Antioxidantes
Límite:
Humans
Idioma:
En
Revista:
Phytochemistry
Año:
2009
Tipo del documento:
Article
País de afiliación:
Tailandia