Lipofuscin and autofluorescence metrics in progressive STGD.
Invest Ophthalmol Vis Sci
; 50(8): 3907-14, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-19387078
ABSTRACT
PURPOSE:
To evaluate Stargardt disease (STGD) progression and relative lipofuscin levels via autofluorescence image analysis.METHODS:
The relationship between focally increased autofluorescence (FIAF), geographic atrophy (GA) and focally decreased autofluorescence (FDAF) was analyzed in serial, registered autofluorescence (AF) scans of 10 patients with STGD (20 eyes, 40 scans; mean follow-up, 2.0 years) using automated techniques.RESULTS:
GA progressed uniformly in a transition zone with minimal FIAF. Only 4.3% of FIAF progressed to GA or FDAF, despite significant progression of GA (median 30%/year) and FDAF (mean, 29%/year). As a spatial predictor, the mean chance of FIAF for progression to FDAF was 4.3% +/- 4.4%, significantly less than that of random areas (6.7% +/- 4.0%, P = 0.029, Mann-Whitney test). In the seven eyes with GA, the mean chance of FIAF in the transition zone for transition to GA was 12% +/- 8.9%, significantly less than that of random areas (33% +/- 3.6%, P = 0.026, Mann-Whitney test).CONCLUSIONS:
Autofluorescent flecks and FIAF deposits with AF levels elevated above the initial macular background were less likely in the short term (2 years) to transform to GA and FDAF (AF levels below the final background) than random areas, suggesting additional mechanisms beyond direct lipofuscin toxicity. FIAF/FDAF levels were observed to fluctuate, with focal remodeling of FIAF and FDAF, or rarely, even transition of FDAF to FIAF. FDAF tended to develop, not coincident with, but adjacent to initial FIAF. Because AF identifies these characteristic biological markers so specifically, autofluorescence metrics merit consideration in the study of STGD.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Atrofia Óptica
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Epitelio Pigmentado de la Retina
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Fluorescencia
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Lipofuscina
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Degeneración Macular
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos