Bacteriophage content of M49 strains of Streptococcus pyogenes.
FEMS Microbiol Lett
; 294(1): 9-15, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19493003
ABSTRACT
Bacteriophages are common autonomous migrating mobile genetic elements in group A Streptococcus (GAS) and are often associated with the carriage of various virulence genes, including toxins, mitogens and enzymes. Two collections of GAS type M49 strains isolated from invasive (22 strains) and noninvasive (16 strains) clinical cases have been studied for the presence of phage and phage-associated virulence genes. All the GAS strains carried from at least two to six phage genomes as determined by the number of known phage integrase genes found. A sampling of the invasive M49 strains showed that they belonged to the same multilocus sequence typing type, carried two specific integrase genes (int5 and int7), and contained the toxin genes speA, speH and speI. Other invasive strains lacking this gene profile carried the prophage integrating in mutL-mutS region and inducing the 'mutator' phenotype. We suggest that this specific phage-related virulence gene constellation might be an important factor increasing M49 GAS pathogenicity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Streptococcus pyogenes
/
Fagos de Streptococcus
/
Profagos
Límite:
Humans
Idioma:
En
Revista:
FEMS Microbiol Lett
Año:
2009
Tipo del documento:
Article
País de afiliación:
Rusia