Growth of dengue type 2 virus isolates in human peripheral blood leukocytes correlates with severe and mild dengue disease.
Am J Trop Med Hyg
; 45(5): 644-51, 1991 Nov.
Article
en En
| MEDLINE
| ID: mdl-1951875
ABSTRACT
We tested three dengue type 2 (DEN-2) isolates from children with clinically apparent but mild secondary dengue infections, and 10 isolates from children with moderately severe dengue hemorrhagic fever, and noted significant growth differences in peripheral blood leukocytes, but not in C6/36 cells. We also observed cytopathic effects in C6/36 cells that correlated with disease severity. These preliminary observations suggest the possibility that viral factors, whether surface antigens, attachment sites for entry into leukocytes, or intrinsic replication properties in human mononuclear phagocytes, might contribute to enhanced DEN infection and to the severity of the disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dengue
/
Virus del Dengue
/
Leucocitos
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
1991
Tipo del documento:
Article