Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches.
J Allergy Clin Immunol
; 124(1): 23-34; quiz 35-6, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19560576
ABSTRACT
The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Virosis
/
Preparaciones Farmacéuticas
/
Mucosa Respiratoria
/
Sistema Inmunológico
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Allergy Clin Immunol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido