[Prevalence of anti-thyroid peroxidase and anti-adrenal 21-hidroxylase in type 1 diabetes patients]. / Prevalência do anti-TPO e anti-21-hidroxilase no paciente diabético tipo 1.
Arq Bras Endocrinol Metabol
; 53(4): 461-5, 2009 Jun.
Article
en Pt
| MEDLINE
| ID: mdl-19649385
ABSTRACT
UNLABELLED There is still no consensus about the best strategy to screen Addison's disease (AD) in type 1 diabetes mellitus (T1DM) patients. OBJECTIVE:
The aim of this study was to determine the frequency of anti-21-hydroxilase (anti-21OH) in a multiethnic T1DM population and investigate if its presence is associated with any adrenal dysfunction or thyroid autoimmunity.METHODS:
Forty individuals underwent an interview and blood was drawn for anti-thyroperoxidase (anti-TPO), anti-21OH, TSH, free T4 and cortisol measurement.RESULTS:
Anti-21OH was found in 7.5% (n = 3), none with adrenal dysfunction. This antibody was not exclusively seen in patients with anti-TPO (+). Anti-TPO was positive in 25% and associated with higher TSH levels (p = 0.034) and older age (p = 0.009).CONCLUSIONS:
Although the frequency of anti-TPO in this sample was similar to previous studies, a higher prevalence of anti-21-OH was found. However, no coexisting adrenal dysfunction was detected, which does not support universal screening for AD in this group.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Esteroide 21-Hidroxilasa
/
Diabetes Mellitus Tipo 1
/
Yoduro Peroxidasa
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Pt
Revista:
Arq Bras Endocrinol Metabol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Brasil