Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.
Bioorg Med Chem Lett
; 19(19): 5531-8, 2009 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-19726182
ABSTRACT
We describe design, syntheses and structure-activity relationships of a novel class of 4,6-disubstituted quinazoline glucokinase activators. Prototype quinazoline leads (4 and 5) were designed based on the X-ray analyses of the previous 2-aminobenzamide lead classes. Modifications of the quinazoline leads led to the identification of a potent GK activator (21d).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinazolinas
/
Glucoquinasa
/
Hipoglucemiantes
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón