Murine neonatal infection provides an efficient model for congenital ocular toxoplasmosis.
Exp Parasitol
; 124(2): 190-6, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-19755119
ABSTRACT
Congenital infection is one of the most serious settings of infection with the apicomplexan parasite Toxoplasma gondii. Ocular diseases, such as retinochoroiditis, are the most common sequels of such infection in utero. However, while numerous studies have investigated the physiopathology of acquired toxoplasmosis, congenital infection has been largely neglected so far. Here, we establish a mouse model of congenital ocular toxoplasmosis. Parasite load and ocular pathology have been followed for the first 4 weeks of life. Ocular infection developed slowly compared to cerebral infection. Even after 4 weeks, not all eyes were infected and ocular parasite load was low. Therefore, we evaluated a scheme of neonatal infection to overcome problems associated with congenital infection. Development of infection and physiopathology was similar, but at a higher, more reliable rate. In summary, we have established a valuable model of neonatal ocular toxoplasmosis, which facilitates the research of the underlying physiopathological mechanisms and new diagnostic approaches of this pathology.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Toxoplasmosis Ocular
/
Modelos Animales de Enfermedad
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Exp Parasitol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia