[Application of fluorescence in situ hybridization in prenatal diagnosis of complex chromosomal abnormalities].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 26(5): 529-32, 2009 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-19806574
ABSTRACT
OBJECTIVE:
To investigate the application of fluorescence in situ hybridization (FISH) technique in prenatal diagnosis of complex chromosomal abnormalities.METHODS:
Eleven prenatal diagnosis cases (8 from amniocentesis and 3 from cord blood) with complex chromosomal abnormalities detected by routine G-banding, were further analyzed by FISH.RESULTS:
The FISH technique confirmed the results of balanced chromosome rearrangements detected by G-banding, and clarified the structure of the derivative chromosomes in the 3 amniocentesis samples and the origin of the mark chromosomes in the 2 cord blood samples.CONCLUSION:
FISH can be used to diagnose the complex chromosomal abnormalities accurately in prenatal diagnosis, and can provide very useful genetic information for clinical diagnosis and treatment.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diagnóstico Prenatal
/
Embarazo
/
Aberraciones Cromosómicas
/
Hibridación Fluorescente in Situ
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Female
/
Humans
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Asunto de la revista:
GENETICA MEDICA
Año:
2009
Tipo del documento:
Article